Organ-on-a-chip Market 2022 Global Opportunities and forecast to 2030
Organ-On-a-Chip
Market (OOC) is expected to hold a value of USD 115.9
Million by 2030 at a CAGR of 11.80%.
Organs-on-chips
(OOCs) are small plastic devices with biocompatible microfluidic chambers,
which contain multiple live human cells in a 3D culture that simulate crucial
physiological functions of body organs. These cells are placed in an
environment that artificially replicates aspects of the human body, such as
morphology, movement, flow, electrical stimuli, and liquid gradients.
The global
organ-on-a-chip market is growing owing to various reasons, such as an increase
in the number of collaborative sales agreements between pharmaceutical
companies and university spin-offs and the availability of advanced models of
OOCs in the market. The anticipated launch of advanced organ-specific models
and human-on-chip models is expected to further increase the growth rate of
this market during the review period.
Grants by
government and non-government entities have been the key drivers for the global
OOC industry to date. The ability of OOC models to reduce drug development
costs drastically will be a key market driver, which is also expected to fuel
market growth. However, stringent drug regulatory processes constitute a
significant restraint for the widespread use of OOCs by pharmaceutical
companies. Drug regulatory authorities scrutinize the preclinical and clinical
investigational data of a drug molecule to validate and approve it. The data
generated by testing the drug in animal models and humans are required for the
drug approval process.
At present, the
regulatory authorities do not consider the data obtained by testing the drugs
on OOCs sufficient for approval. Data predicting the efficacy of a drug
molecule obtained by the chips can be submitted but only along with the trial
data from animal and human subjects for the approval process. These drug
regulations limit the use of OCCs by end-users are expected to hinder the
growth of the global organ-on-a-chip market.
Several market
players currently dominate the global organ-on-a-chip market. The key players
are involved in product launches and acquisitions to strengthen their market
positions.
Major Key
Players:
Some of the Organ-on-a-Chip Market Players are CN Bio Innovations
Limited (UK), Emulate, Inc. (US), TissUse GmbH (Germany), MIMETAS BV
(Netherlands), Hµrel Corporation, Nortis, Inc. (US), InSphero (Switzerland),
TARA Biosystems, Inc. (US), Axosim (US), Organovo Holdings Inc. (US), BioIVT
(US), and HemoShear Therapeutics, LLC (US).
Segment Analysis
The global organ on a chip market has been
segmented based on organ type, application, and end-user.
The global organ-on-a-chip market has been
segregated, based on organ type, into lung-on-chip, heart-on-chip,
liver-on-chip, intestine-on-chip, kidney-on-chip, skin-on-chip, blood-brain
barrier-on-chip, human-on-chip, and others.
The market based on application has been
branched into drug discovery, toxicology research, and others. The drug
discovery segment is expected to hold the largest share of the market due to
the increased application of OOCs by pharmaceutical companies in drug discovery
and clinical trials for the different chronic therapeutic areas. The toxicology
research segment holds the second-largest share owing to increased R&D,
government initiatives and funding for research institutes, and universities on
OOCs in toxicology research and drug testing.
By end-user, the market has been classified as
pharmaceutical companies, research organizations, and others. The
pharmaceutical company’s segment is the largest segment owing to the rise in
the number of pharmaceutical companies using OOCs for their R&D and drug
toxicity and efficacy testing. The research organization segment is the second-largest
segment owing to major universities, research organizations, non-profit
research centers that are focusing on the application of OOCs in drug
toxicology testing. For instance, the Wyss Institute received almost USD 5.6
million in grant money from the US FDA to use its organ-on-chip technology to
test human physiological responses to radiation and to evaluate drugs designed
to counter those effects in 2017.
Regional Analysis
The market has been divided, by
region, into the Americas, Europe, Asia-Pacific, and the Middle East &
Africa. The Americas is expected to be the largest market owing to the high
prevalence of chronic diseases. The organ-on-a-chip market in the Americas has
further been branched into North America and Latin America, with the North
American market divided into the US and Canada. The European organ-on-a-chip
market has been categorized as Western Europe and Eastern Europe. The Western
European market has further been classified as Germany, France, the UK, Italy,
Spain, and the rest of Western Europe. The organ-on-a-chip market in
Asia-Pacific has been segmented into Japan, China, India, South Korea,
Australia, and the rest of Asia-Pacific.
Asia-Pacific is the
fastest-growing region in the market. This is mainly due to the increased application
of OOCs for drug screening for the treatment of various chronic diseases and a
supportive regulatory framework in Asia-Pacific. Such favorable factors are
expected to boost market growth during the forecast period.
The organ-on-a-chip market in the
Middle East & Africa has been divided into the Middle East and Africa.
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